Natchus, M. G.: search on Z-Library

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1

Identification and Characterization of Influenza Virus Entry Inhibitors Through Dual-Myxovirus High-Throughput Screening

Weisshaar, Marco, Cox, Robert, Morehouse, Zachary, Kyasa, ShivaKumar, Yan, Dan, Oberacker, Phil, Mao, Shuli, Golden, Jennifer E, Lowen, Anice C, Natchus, Michael G, Plemper, Richard K

Journal:

Journal of Virology

Year:

2016

File:

PDF, 5.04 MB

2016

2

Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

M. J. Janusz, E. B. Hookfin, K. K. Brown, L. C. Hsieh, S. A. Heitmeyer, Y. O. Taiwo, M. G. Natchus, S. Pikul, N. G. Almstead, B. De S. X. Peng, T. R. Baker, V. Patel

Journal:

Inflammation Research

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

3

Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics

Ndungu, J. Maina, Krumm, Stefanie A., Yan, Dan, Arrendale, Richard F., Reddy, G. Prabhakar, Evers, Taylor, Howard, Randy, Natchus, Michael G., Saindane, Manohar T., Liotta, Dennis C., Plemper, Richard

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

4

330 FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS IN VIVOPROSTATE CANCER EFFICACY

Mays, Suzanne G., Baillie, Mark T., Miller, Eric J., Bushnev, Anatoliy S., Pruett, Sarah T., Culver, Deborah G., Evers, Taylor J., Gao, Jingjing, Reddy, G. Prakabahr, Natchus, Michael G., Arrendale, R

Journal:

The Journal of Urology

Year:

2013

Language:

english

File:

PDF, 177 KB

english, 2013

5

ChemInform Abstract: Oxazolidinone to Succinamide: A Novel Rearrangement Reaction.

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Year:

1999

File:

PDF, 27 KB

1999

6

Chemoenzymatic synthesis of functionalized cyclohexylglycines and α-methylcyclohexylglycines via Kazmaier–Claisen rearrangement

Tomas Hudlicky, Kofi Oppong, Caiming Duan, Charles Stanton, Matthew J. Laufersweiler, Michael G. Natchus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

7

Improved Practical Synthesis of a Prostaglandin and Carbocyclic Nucleoside Synthon

Hudlicky, Tomas, Natchus, Michael G., Nugent, Thomas C.

Journal:

Synthetic Communications

Year:

1992

Language:

english

File:

PDF, 276 KB

english, 1992

8

Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

Natchus, Michael G., Bookland, Roger G., De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Janusz, Michael J., Heitmeyer, Sandra A., Hookfin, Erin B., Hsieh, Lily C., Dowty, Martin E., Dietsch, Char

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 398 KB

english, 2000

9

An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model

Krumm, S. A., Yan, D., Hovingh, E. S., Evers, T. J., Enkirch, T., Reddy, G. P., Sun, A., Saindane, M. T., Arrendale, R. F., Painter, G., Liotta, D. C., Natchus, M. G., von Messling, V., Plemper, R. K.

Journal:

Science Translational Medicine

Year:

2014

Language:

english

File:

PDF, 700 KB

english, 2014

10

ChemInform Abstract: Chemoenzymatic Synthesis of Functionalized Cyclohexylglycines and α-Methylcyclohexylglycines via Kazmaier—Claisen Rearrangement.

Tomas Hudlicky, Kofi Oppong, Caiming Duan, Charles Stanton, Matthew J. Laufersweiler, Michael G. Natchus

Journal:

Year:

2001

File:

PDF, 37 KB

2001

11

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Joshua S. Tullis, Matthew J. Laufersweiler, John C. VanRens, Michael G. Natchus, Roger G. Bookland, Neil G. Almstead, Stanislaw Pikul, Biswanath De, Lily C. Hsieh, Michael J. Janusz, Todd M. Branch, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

12

Development of a novel progesterone analog in the treatment of traumatic brain injury

Sayeed, Iqbal, Wali, Bushra, Guthrie, David B., Saindane, Manohar T., Natchus, Michael G., Liotta, Dennis C., Stein, Donald G.

Journal:

Neuropharmacology

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

13

The Asymmetric Synthesis of Unnatural α-Amino Acids as Building Blocks for Complex Molecule Synthesis

Michael G. Natchus, Xinrong Tian

Journal:

Year:

2003

File:

PDF, 59 KB

2003

14

Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Pikul, Stanislaw, Ohler, Norman E., Ciszewski, Greg, Laufersweiler, Michael C., Almstead, Neil G., De, Biswanath, Natchus, Michael G., Hsieh, Lily C., Janusz, Michael J., Peng, Sean X., Branch, Todd M

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

15

Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Sticher, Zachary M., Lu, Gaofei, Mitchell, Deborah G., Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R., Guthrie, David B., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2019

File:

PDF, 1.16 MB

2019

16

Host-Directed Inhibitors of Myxoviruses: Synthesis and in Vitro Biochemical Evaluation

Sun, Aiming, Ndungu, J. Maina, Krumm, Stefanie A., Yoon, Jeong-Joong, Thepchatri, Pahk, Natchus, Michael, Plemper, Richard K., Snyder, James P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

17

Automated 96-Well SPE and LC−MS−MS for Determination of Protease Inhibitors in Plasma and Cartilage Tissues

Peng, Sean X., King, Salane L., Bornes, David M., Foltz, David J., Baker, Timothy R., Natchus, Michael G.

Journal:

Analytical Chemistry

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

18

Stereocontrolled total synthesis of pentalenenes via [2 + 3] and [4 + 1] cyclopentene annulation methodologies

Hudlicky, Tomas, Natchus, Michael G., Sinai-Zingde, Gurudas

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 492 KB

english, 1987

19

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold.

Michael G. Natchus, et al. et al.

Journal:

Year:

2000

File:

PDF, 30 KB

2000

20

Oxazolidinone to succinamide: a novel rearrangement reaction

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

21

ChemInform Abstract: Studies in the Regioselectivity of the Vinylogous Reformatsky Reaction with Ambident Electrophiles: Reversibility, Mechanism and Synthetic Utility.

HUDLICKY, T., NATCHUS, M. G., KWART, L. D., COLWELL, B. L.

Journal:

Chemischer Informationsdienst

Year:

1986

File:

PDF, 118 KB

1986

22

ChemInform Abstract: The Next Generation of MMP Inhibitors: Design and Synthesis

Biswanath De, Michael G. Natchus, Menyan Cheng, Stanislaw Pikul, Neil G. Almstead, Yetunde O. Taiwo, Catherine E. Snider, Longyin Chen, Bobby Barnett, Fei Gu, et al. et al.

Journal:

Year:

1999

File:

PDF, 26 KB

1999

23

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Almstead, Neil G., Bradley, Rimma S., Pikul, Stanislaw, De, Biswanath, Natchus, Michael G., Taiwo, Yetunde O., Gu, Fei, Williams, Lisa E., Hynd, Barbara A., Janusz, Michael J., Dunaway, C. Michelle, M

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 507 KB

english, 1999

24

Chemoenzymic enantiocontrolled synthesis of (-)-specionin

Hudlicky, Tomas, Natchus, Michael

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 1.02 MB

english, 1992

25

ChemInform Abstract: (2 + 3)Cyclopentene Annulation and Other Trimethylsilyl Iodide-Mediated Rearrangement Pathways of Vinylcyclopropanes.

FLEMING, A., SINAI-ZINGDE, G., NATCHUS, M., HUDLICKY, T.

Journal:

Year:

1987

File:

PDF, 133 KB

1987

26

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Cheng, Menyan, De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Dowty, Martin E., Dietsch, Charles R., Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C., Janusz, Michael J., Taiwo, Yetunde O., Natchus,

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 282 KB

english, 1999

27

Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy

Moore, Terry W., Sana, Kasinath, Yan, Dan, Krumm, Stefanie A., Thepchatri, Pahk, Snyder, James P., Marengo, José, Arrendale, Richard F., Prussia, Andrew J., Natchus, Michael G., Liotta, Dennis C., Ple

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

28

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats

Wali, Bushra, Sayeed, Iqbal, Guthrie, David B., Natchus, Michael G., Turan, Nefize, Liotta, Dennis C., Stein, Donald G.

Journal:

Neuropharmacology

Year:

2016

Language:

english

File:

PDF, 2.28 MB

english, 2016

29

Toward the synthesis of taxol and its analogs: Incorporation of non-aromatic C-rings in the pinene pathway

Paul A. Wender, Paul E. Floreancig, Timothy E. Glass, Michael G. Natchus, Anthony J. Shuker, James C. Sutton

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 229 KB

english, 1995

30

The Next Generation of MMP Inhibitors: Design and Synthesis

BISWANATH DE, MICHAEL G. NATCHUS, MENYAN CHENG, STANISLAW PIKUL, NEIL G. ALMSTEAD, YETUNDE O. TAIWO, CATHERINE E. SNIDER, LONGYIN CHEN, BOBBY BARNETT, FEI GU, MARTIN DOWTY

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 711 KB

english, 1999

31

ChemInform Abstract: Stereocontrolled Total Synthesis of Pentalenenes via (2 + 3) and (4 + 1) Cyclopentene Annulation Methodologies.

HUDLICKY, T., NATCHUS, M. G., SINAI-ZINGDE, G.

Journal:

Year:

1988

File:

PDF, 164 KB

1988

32

Design and synthesis of conformationally-constrained MMP inhibitors

Michael G. Natchus, Menyan Cheng, Christopher T. Wahl, Stanislaw Pikul, Neil G. Almstead, Rimma S. Bradley, Yetunde O. Taiwo, Glen E. Mieling, C.Michelle Dunaway, Catherine E. Snider, John M. McIver,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 272 KB

english, 1998

33

Quantitative Efficacy Paradigms of the Influenza Clinical Drug Candidate EIDD-2801 in the Ferret Model

Toots, Mart, Yoon, Jeong-Joong, Hart, Michael, Natchus, Michael G., Painter, George R., Plemper, Richard K.

Journal:

Translational Research

Year:

2019

Language:

english

File:

PDF, 1.47 MB

english, 2019

34

The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production

Joshua S Tullis, John C VanRens, Michael G Natchus, Michael P Clark, Biswanath De, Lily C Hsieh, Michael J Janusz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

35

ChemInform Abstract: Toward the Total Synthesis of Taxol and Its Analogues

P. A. WENDER, M. G. NATCHUS, A. J. SHUKER

Journal:

Year:

1996

File:

PDF, 25 KB

1996

36

The Development of New Triazole Based Inhibitors of Tumor Necrosis Factor-α (TNF-α) Production.

Joshua S. Tullis, John C. VanRens, Michael G. Natchus, Michael P. Clark, Biswanath De, Lily C. Hsieh, Michael J. Janusz

Journal:

Year:

2003

Language:

english

File:

PDF, 138 KB

english, 2003

37

Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines

Natchus, Michael G., Bookland, Roger G., Laufersweiler, Matthew J., Pikul, Staszek, Almstead, Neil G., De, Biswanath, Janusz, Michael J., Hsieh, Lily C., Gu, Fei, Pokross, Matthew E., Patel, Vikram S.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 326 KB

english, 2001

38

Synthesis of .beta.-methoxy enones via a new two-carbon extension of carboxylic acids

Hudlicky, Tomas, Olivo, Horacio F., Natchus, Michael G., Umpierrez, Eleuterio F., Pandolfi, Enrique, Volonterio, Carla

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 645 KB

english, 1990

39

Studies in the regioselectivity of the vinylogous Reformatsky reaction with ambident electrophiles: reversibility, mechanism, and synthetic utility

Hudlicky, Tomas, Natchus, Michael G., Kwart, Larry D., Colwell, Barry L.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 912 KB

english, 1985

40

Asymmetric synthesis of host-directed inhibitors of myxoviruses

Moore, Terry W, Sana, Kasinath, Yan, Dan, Thepchatri, Pahk, Ndungu, John M, Saindane, Manohar T, Lockwood, Mark A, Natchus, Michael G, Liotta, Dennis C, Plemper, Richard K, Snyder, James P, Sun, Aimin

Journal:

Beilstein Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

41

ChemInform Abstract: Design and Synthesis of Conformationally-Constrained MMP Inhibitors.

M. G. NATCHUS, B. DE, ET AL. ET AL.

Journal:

Year:

1998

File:

PDF, 39 KB

1998

42

ChemInform Abstract: Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines.

Michael G. Natchus, et al. et al.

Journal:

Year:

2001

Language:

english

File:

PDF, 34 KB

english, 2001

43

Solid-phase synthesis of functionalized 1,2,3-triazoles

Benjamin E Blass, Keith R Coburn, Amy L Faulkner, Cheryl L Hunn, Michael G Natchus, M.Sharon Parker, David E Portlock, Joshua S Tullis, Richard Wood

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

44

Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Cheng, Menyan, De, Biswanath, Pikul, Stanislaw, Almstead, Neil G., Natchus, Michael G., Anastasio, Melanie V., McPhail, Sara J., Snider, Catherine E., Taiwo, Yetunde O., Chen, Longyin

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 531 KB

english, 2000

45

Quantitative Efficacy Paradigms of the Influenza Clinical Drug Candidate EIDD-2801 in the Ferret Model

Toots, Mart, Yoon, Jeong-Joong, Hart, Michael, Natchus, Michael G., Painter, George R., Plemper, Richard K.

Journal:

Translational Research

Year:

2019

File:

PDF, 1.47 MB

2019

46

[2+3] Cyclopentene annulation and other trimethylsilyl iodide-mediated rearrangement pathways of vinylcyclopropanes

Alison Fleming, Gurudas Sinai-Zingde, Michael Natchus, Tomas Hudlicky

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 196 KB

english, 1987

47

Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors

M.J. Janusz, E.B. Hookfin, S.A. Heitmeyer, J.F. Woessner, A.J. Freemont, J.A. Hoyland, K.K. Brown, L.C. Hsieh, N.G. Almstead, B. De, M.G. Natchus, S. Pikul, Y.O. Taiwo

Journal:

Osteoarthritis and Cartilage

Year:

2001

Language:

english

File:

PDF, 7.11 MB

english, 2001

48

β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome

Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K., Sokratian, Arpine, Guthrie, David B., Kolykhalov, Alexander A., Lockwood, Mark A., Natchus, Michael G., Crowley, Michael R., Painter, George R

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 1.78 MB

english, 2017

49

Small molecule antiviral β-D- N 4 -hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance

Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, M

Journal:

Journal of Virology

Year:

2019

Language:

english

File:

PDF, 1.93 MB

english, 2019

50

Selective reduction of α,β-unsaturated esters in the presence of olefins

T. Hudlicky, G. Sinai-Zingde, M.G. Natchus

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 180 KB

english, 1987

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